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I can't agree more with you two on this. I watched the trailer a week ago and it put a bad taste in my mouth. Basically, all they did was replace the original characters with female equivalents. You have your Murry, Aykryod, Ramis and Hudson. The "Hudson" character even has the same line of "You guys know this science stuff" (or however it goes). I'm surprised they kept the "race ratio" as well.
Then, they bring SNL humor into it. Granted, the last one sort of had that same type of humor, but SNL humor from the 80's is completely different from the SNL humor of today, which most would say is greatly lacking in the laughs department. I'm surprised that Kristen Wiig and Melissa McCarthy's humor is still so popular. Which brings me to my final point of why this movie is probably going to flop.
Look at the past two decades of comedy. You have your Adam Sandlers, Eddie Murphys etc, and now you have your Wiigs/McCarthys. Most comedians, once they find their rhythm, they never leave it, after all, it made them money. I think they begin to fall into the trap of repeating themselves. No one wants to hear Adam Sandler say "hiney"anymore, and most comedy fans don't want to go see another Nutty Professor movie. We are now living in the days of dead pan humor. If my calculations are correct, fans will become bored with Wiig's/McCarthy's dead pan deliveries as well, if they haven't already. It may not be the critic who counts on this one, but it really looks like they are trying too hard with this movie..